High BUN cat kidney disease I resume my studies on what are the new substances able to reduce the high azotemia cat … about three years ago in this article (complex research that involved me several days), I explained how the uremic toxins in the course of CKD can be reduced with the administration of specific strains, probiotics (VIVOMIXX + YAKULT ) but also prebiotics (INULIN) capable of phagocytizing Indole sulfate, p-cresyl sulfate.
HIGH AZOTEMIA DOG CAT
In chronic renal failure the intestinal microbiota is directly involved in the increase of uremic toxins, because it is the dysbiosis induced by the uremia itself that increases the concentrations of toxins in the circulation with consequent reduction of renal excretion and worsening of the disease.
Uremic toxin: the Indol sulfate, p-cresyl sulfate and the microbiota L ‘ indoxyl sulfate is a metabolite of tryptophan food that acts as a cardiotoxin and uremic toxin. In humans, high concentrations of this metabolite in the blood are associated with the development and progression of chronic kidney disease, being a uremic toxin, it stimulates glomerular sclerosis and renal interstitial fibrosis. Studies suggest that: Patients with CKD develop higher plasma TMAO levels and a different composition of the gut microbiota than healthy subjects. The increase in TMAO levels in CKD patients is directly caused by dysbiosis of the microbiota.
- TMAO (trimelitalamine-N-oxide) → cardiovascular risk and thrombosis
- indoxyl sulfate → renal disease progression thrombosis, cardiovascular disease, anemia
- p-cresyl sulfate → renal and vascular disease progression, pro-inflammatory effects
The intestinal microbiota affects the production of uremic toxins essentially linked to proteins and the uremia in turn influences the composition of the intestinal microbiota. This reciprocal influence does nothing but causes disturbances and deficits in the intestinal mucosa and damage to the bacterial flora with consequent symptoms affecting the intestine:
- He retched
- Lack of appetite
From the studies, research and experience that I have conducted in this last year 2020-2021 I tell you that we can effectively decrease the production of uremic toxins such as
- p-cresyl sulfate
- indoxyl sulfate
L. casei Shirota (Yakult)
November 2021 – I resume research on p-cresyl sulfate and indoxyl sulfate and finally after researches on foreign sites from Japan to China via Korea I arrive in Europe … wuaoo! I’m telling you about another supplement that I had seen a few months ago but which was not yet available in Europe.
Before I reveal the name of this product, I will bring you my research … This supplement was first approved in Japan in 1991 to relieve uremic symptoms and delay the need for dialysis in CKD patients. It was subsequently approved in Korea, Taiwan and the Philippines again for the treatment of human patients with CKD, has the ability to absorb and remove uremic toxins from the intestine, consequently reduces kidney damage and delays chronic renal failure. This supplement “chelates” (it is not a phosphorus chelator) indoxyl sulfate (IS), derived from the metabolism of tryptophan, a nephro-vascular uremic toxin that also plays a role in the immune response and neurodegeneration. When this product is administered orally to patients (in human) with chronic renal failure, it improves uremic symptoms and prolongs the time of initiation of dialysis (in human) as uremic toxins are absorbed by this product in the digestive tract and then excreted with the faeces. It has an inhibitory effect on the decrease of glomerular filtration function and inhibition of the aggravation of renal tissue lesion and inhibits the increase in serum creatinine. Effectively slows the progression of glomerular sclerosis, tubulointerstitial fibrosis and proximal tubular hypertrophy.
Improves the symptoms of uremia in patients with chronic renal failure.
The product in human is called: AST-120 is an orally administered adsorbent, consisting of spherical particles of 0.2-0.4 mm in diameter.
It is mainly composed of carbon and can absorb toxins and uremic precursors, such as indoxyl sulfate (IS), causing their subsequent excretion in the faeces.
AST-120 is marketed under the name kremezin or Remenzin (capsules). Renamezin is a new capsule-shaped spherical carbon oral sorbent that can replace Kremezin. (not available in Italy / Europe).
The new product in the veterinary is called: Porus One (Renaltec) for use only in cats. This adsorbent consists of small homogeneous black spheres with a diameter of 0.1-0.3 mm with a smooth surface.
Porus One cats
The pore size of Porus One® is regulated in such a way that it absorbs small molecules in a targeted way, but not macromolecules (such as vitamins) or cells. After the absorption of uremic toxin precursors, such as indole and p-cresol, Porus One is completely eliminated in the faeces.
It is intended for oral use and remains about 12 to 36 hours in the intestine. The elimination of Porus One depends on the intestinal activity.
Recommended for supporting kidney health in cats.
One sachet (500 mg) is administered per day per cat meal